GE Healthcare HiTrap™ MabSelect™ Prepacked Columns

Use these columns in small-scale MAb purification in a continuous bioprocess. GE Healthcare Life Sciences™ HiTrap™ MabSelect™ Prepacked Columns for fast purification of monoclonal antibodies (Mabs) from large sample volumes

Overview
Brand: GE Healthcare

Manufacturer Part Number: 28408258

X5 HITRAP MABSELECT XTRA 1ML STORE IN FRIDGE AT 4C

UNSPSC: 41116104

Code: GE

Additional Details:
Additional Details: Weight: 0.50000kg



Product Code. 10106234

Quantity Price
1 £ 585.02 / Pack of 5
Estimated Shipment
20-12-2016
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Description and Specification

Specification

Quantity 5 Pack
Diameter (Metric) Inner Column 0.7cm
Binding Capacity ≈40mg Human lgG/mL at 2.4 min. residence time
Flow Rate <4mL/min.
For Use With (Application) For fast purification of monoclonal antibodies from large sample volumes, Protein Purification
Storage Buffer 20% Ethanol
Storage Requirements 4° to 30°C
Sample Volume 1mL
Volume (Metric) Bed 1mL

Prepacked HiTrap columns for process development, screening of purification conditions, and small-scale purification of Mabs. MabSelect media are suited for the high flowrates and pressures required when scaling up.

  • Oriented coupling of recombinant Protein A ligand to the agarose matrix via an engineered C-terminal cysteine increases IgG binding capacity over other protein A media
  • High capacity, low ligand leakage, and high-flow base matrix allow purification of Mabs at process scale
  • Fewer regulatory concerns due to the total absence of mammalian culture in the ligand production and purification
  • Designed for use with a syringe, a peristaltic pump, or a chromatography system

MabSelect

  • Allows at least five times higher flowrates than conventional cross-linked agarose of similar porosity
  • Recombinant Protein A ligand promotes specificity of binding to Fc region of IgG; permits one-step purification
MabSelect Xtra™
  • Same recombinant protein A ligand as MabSelect, but with a smaller particle size and greater porosity, for increased dynamic binding capacity
  • Allows binding from samples with high expression levels of the monoclonal antibody
  • Lowers overall production cost due to the possibility of processing concentrated feedstocks in fewer batches
MabSelect SuRe™ (Superior Resistance)
  • Akali-tolerant protein A-derived ligand allows the use of up to 0.5M NaOH for cleaning-in-place (CIP)
  • Permits significant cost savings and extension of cycles in regular production