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GDC-0623, MedChemExpress

Product Code. p-200102201
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Product Code. 16499237

Brand: Medchem Express HY15610

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Description

MedChemExpress GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).

GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).

Specifications

Chemical Name or Material GDC-0623
CAS 1168091-68-6
Color Yellow
Purity Grade Notes Research
Molecular Formula C16H14FIN4O3
Quantity 5 mg
Synonym RG 7421 MEK inhibitor 1
Solubility Information DMSO : 50 mg/mL (109.60 mM; Need ultrasonic)
SMILES FC(C=C(I)C=C1)=C1NC2=C(C(NOCCO)=O)C=CC3=CN=CN23
Molecular Weight (g/mol) 456.21
Formula Weight 456.21
Percent Purity 95.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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