Invitrogen™ GATAD2A Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA555065

Product Code. 15752991

Description

Immunogen sequence: LERDPTEDDV ESKKIKMERG LLASDLNTDG DMRVTPEPGA GPTQGLLRAT EATAMAMGRG EGLVGDGPVD MRTSHSDMKS ERRPPSPDVI VLSDNEQPSS PRVNGLTTVA LKETSTE Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 79%.

GATAD2A is a gene encoding a protein that functions as a subunit of the nucleosome remodeling and deacetylase (NuRD) complex, which plays a crucial role in chromatin remodeling and gene expression regulation. Located on the human chromosome, GATAD2A contains proline-rich PPPL theta motifs that facilitate interactions with MYND domains in proteins such as ZMYND8, distinguishing it from its paralog GATAD2B. This gene is important for various cellular processes, particularly during neural development, where it participates in modulating chromatin structure through histone deacetylation and ATP-dependent remodelings, like those mediated by NuRD. Moreover, GATAD2A has been implicated in certain neurodevelopmental disorders, suggesting its distinct functional roles in cellular contexts. Additionally, research has identified circular RNA variants of GATAD2A, which have been shown to influence viral replication, indicating its broader impact on cellular function beyond chromatin modification.

Specifications

• Antigen: GATAD2A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GATAD2A
• Gene Alias: 1110066C11Rik; BC031407; C80248; GATA zinc finger domain containing 2A; GATA zinc finger domain-containing protein 2A; GATAD2A; Hp66alpha; MGC29315; MGC36975; p66 alpha; p66a; p66alpha; RGD1310596; transcriptional repressor p66 alpha; Transcriptional repressor p66-alpha
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54815
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ChIP Assay, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q86YP4
• Gene Symbols: GATAD2A
• Immunogen: Recombinant protein corresponding to Human GATAD2A. Recombinant protein control fragment (Product #RP-89394).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG