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Gata-3 Rat anti-Human, Mouse, PE-eFluor 610, Clone: TWAJ, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 61-9966-42

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15550587

  • £213.39 / 100 tests


Estimated Shipment date
from Supplier 25-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody TWAJ recognizes mouse and human Gata-3, a member of the Gata family of transcription factors. Gata-3 is a T cell-specific transcription factor important for thymic development and Th2 differentiation. Expression during embryonic development is found in the central nervous system, skin, mammary glands and kidney. During development, the expression of Gata-3 is essential as homozygous knock-out of Gata-3 is embryonic lethal. The Gata-3 is also essential for T cell commitment and survival. In the thymus, expression is found mainly on the CD4 single positive cells. During Th2 differentiation, Gata-3 binds to the IL-4 promoter as well as represses the expression of T-bet, thus inhibiting Th1 differentiation.

Alternative splice variants have been reported especially in the MCF7 cell line. The TWAJ Human/Mouse Gata-3 antibody will recognize both forms (50 and 45 kDa) of the protein.

Staining with the TWAJ Human/Mouse Gata-3 antibody requires the use of the Foxp3/Transcription Factor Staining Buffer Set.
Description & Specifications

Specifications

Gata-3
TWAJ
PE-eFluor 610
Conjugated
IgG2b
RUO
Primary
Murine
Flow Cytometry (Intracellular Staining)
5μL (0.03μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Rat
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal