Invitrogen™ GASP2 Monoclonal Antibody (289802)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA523992

Product Code. 15553682

Description

In direct ELISAs and Western blots, no cross-reactivity with recombinant human GASP-1 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

The GASP2 gene encodes for a protein known as G protein-coupled receptor-associated sorting protein 2. GASP2 is involved in the regulation of G protein-coupled receptors (GPCRs), which are crucial for transmitting signals from the external environment to the inside of a cell. This protein plays a key role in the intracellular trafficking and sorting of GPCRs, affecting their recycling and degradation pathways, which are critical for receptor resensitization and downregulation. GASP2 assists in marking GPCRs for degradation post endocytosis, thereby influencing receptor availability on the cell surface and modulating cellular responsiveness to ligands. Dysregulation of GASP2 expression or function can impact GPCR signaling pathways, potentially affecting various physiological processes and contributing to disease states where GPCR signaling is altered, such as in certain neurological disorders and cancers. The role of GASP2 in GPCR regulation makes it a point of interest for therapeutic targeting to modulate GPCR-related signaling pathways for clinical benefits in diverse diseases.

Specifications

• Antigen: GASP2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q96NZ8
• Gene Symbols: WFIKKN1
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human GASP-2/WFIKKN Ala20-Asp548.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Clone: 289802
• Conjugate: Unconjugated
• Gene: WFIKKN1
• Gene Alias: C16orf12; GASP2; GASP-2; Growth and differentiation factor-associated serum protein 2; hGASP-2; PSEC0040; RJD2; WAP four-disulfide core domain 20A; WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing protein; WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1; WAP, FS, Ig, KU, and NTR-containing protein; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1; WFDC20A; WFIKKN; WFIKKN1
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 117166
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized