GADD45GIP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 16260-1-AP-20UL

Product Code. 16815844

Description

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).

Specifications

• Antigen: GADD45GIP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GADD45GIP1
• Gene Alias: CKBBP2, CKII beta associating protein, CR6 interacting factor 1, CRIF1, GADD45GIP1, p53 responsive gene 6 protein, PLINP 1, Plinp1, PRG6
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 102060, 288916, 90480
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunoprecipitation
• Concentration: 0.35 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8TAE8, Q9CR59
• Gene Symbols: Gadd45gip1
• Immunogen: GADD45GIP1 Fusion Protein Ag9299
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Rat, Human, Mouse
• Product Type: Antibody
• Isotype: IgG