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GAD65 Monoclonal Antibody (ZG002), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen 398200
Code : 50
Additional Details : Weight : 0.50000kg
Description
GAD65 (glutamic acid decarboxylase-65) are present in autoimmune disorders such as insulin-dependent (type1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD.Specifications
GAD65 | |
Monoclonal | |
0.5 mg/mL | |
PBS with 0.1% sodium azide; pH 7.4 | |
P48320, Q05329, Q05683 | |
GAD2 | |
Recombinant protein corresponding to the N-terminal region of the human GAD65 protein | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG1 κ |
ELISA, Immunohistochemistry (Paraffin), Western Blot | |
ZG002 | |
Unconjugated | |
GAD2 | |
6330404F12Rik; 65 kDa glutamic acid decarboxylase; GAD(65); GAD2; Gad-2; GAD65; GAD-65; Glutamate decarboxylase 2; Glutamate decarboxylase 2 (islet); glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 65 kDa isoform; Glutamate decarboxylase-2 (pancreas); glutamic acid decarboxylase 2; glutamic acid decarboxylase 65; MGC161605; MGC161607; RP11-420F12.2 | |
Mouse | |
Protein A | |
RUO | |
14417, 24380, 2572 | |
-20°C | |
Liquid |