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Tocris Bioscience™ G6PDi 1
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Product Code. 30000024
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10 mg
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Product Code. 30000024 Supplier Tocris Bioscience™ Supplier No. 7561/10

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Description

Potent, reversible glucose-6-phosphate dehydrogenase (G6PD) inhibitor

G6PDi 1 is a potent, reversible, nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD) (IC50 = 70 nM. The compound dose-dependently and reversibly decreases 6-phosphogluconolactone (6-PG) levels in HCT116 and HepG2 cell lines in vitro. In activated T cells, G6PDi-1 inhibits flux through the pentose phosphate pathway and decreases NADPH generation. It also inhibits production of cytokines by activated T cells and oxidative burst in neutrophils.
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Specifications

Chemical Name or Material 4-((5-Oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino)thiophene-2-carbonitrile
CAS 2457232-14-1
Quantity 10 mg
Target Glucose 6 Phosphate Dehydrogenase
Molecular Formula C14H12N4OS
Purity 0.98
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