Thermo Scientific Chemicals G418 sulfate, for biochemistry

Product Code	Brand	Quantity	Packaging
10143871	Thermo Scientific Chemicals 329400010	1 g	Glass Bottle
10165633	Thermo Scientific Chemicals 329400050	5 g	Glass Bottle

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea
• G418 is a bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis

Applications

• G418 sulfate can be used for selection of genetically engineered cells in both eukaryotes and prokaryotes
• Laboratory grade for applications such as biochemistry

Chemical Identifiers

• CAS: 108321-42-2
• Molecular Weight (g/mol): 692.70
• InChI Key: UHEPSJJJMTWUCP-KETIWVBHNA-N
• SMILES: OS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O

• Molecular Formula: C20H44N4O18S2
• MDL Number: MFCD00058314
• PubChem CID: 134129582

Specifications

• Type: G418 Sulfate
• CAS: 108321-42-2
• Molecular Formula: C20H44N4O18S2
• Solubility Information: Solubility in water: soluble.
• SMILES: OS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O
• Molecular Weight (g/mol): 692.70
• Formula Weight: 692.7
• Water: 10% max.
• Chemical Name or Material: G418 sulfate

• Physical Form: Powder
• Infrared Spectrum: Authentic
• MDL Number: MFCD00058314
• InChI Key: UHEPSJJJMTWUCP-KETIWVBHNA-N
• IUPAC Name: (2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2S,3S,4R,6S)-4,6-diamino-3-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-(1-hydroxyethyl)oxane-3,4-diol; bis(sulfuric acid)
• PubChem CID: 134129582
• Grade: Biochemical
• Color: White

Safety and Handling

GHS H Statement:
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause an allergic skin reaction.
May damage fertility. May damage the unborn child.

GHS P Statement:
Avoid breathing dust/fume/gas/mist/vapors/spray.
IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing.
If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
Wear eye protection/face protection.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

Product Identifier

• G418 sulfate

Signal Word

• Danger

Hazard Category

• Reproductive toxicity Category 1A
• Respiratory sensitiser Category 1
• Skin sensitiser Category 1

Hazard Statement

• H317-May cause an allergic skin reaction.
• H360FD-May damage fertility. May damage the unborn child.
• H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Precautionary Statement

• P201-Obtain special instructions before use.
• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.
• P342+P311-If experiencing respiratory symptoms: Call a POISON CENTER/doctor/ .

RUO – Research Use Only