G418 disulfate, 50mg/ml solution, Thermo Scientific™

G418 sulfate, geneticin, CAS # 108321-42-2, is an antibiotic closely related to Gentamicin B, the common aminoglycoside antibiotic.

Brand:  Thermo Scientific Alfa Aesar J63871.AD

Product Code. 15446029

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General description

• G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea

• G418 is bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis

Applications

• G418 sulfate can be used for the selection of genetically engineered cells in both eukaryotes and prokaryotes

• Laboratory-grade for applications such as biochemistry

Chemical Identifiers

• CAS: 108321-42-2
• Molecular Weight (g/mol): 692.702
• InChI Key: UHEPSJJJMTWUCP-TUWLDMFGSA-N
• PubChem CID: 134129582
• SMILES: CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O

• Molecular Formula: C20H44N4O18S2
• MDL Number: MFCD00058314
• Synonym: Geneticin
• IUPAC Name: (2R,3R,4R,5R)-2-[(1S,2R,3R,4S,6R)-4,6-diamino-3-[(2S,3S,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid

Specifications

• CAS: 108321-42-2
• Concentration: 50mg/ml solution
• Molecular Formula: C20H44N4O18S2
• Synonym: Geneticin
• InChI Key: UHEPSJJJMTWUCP-TUWLDMFGSA-N
• IUPAC Name: (2R,3R,4R,5R)-2-[(1S,2R,3R,4S,6R)-4,6-diamino-3-[(2S,3S,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
• PubChem CID: 134129582
• Chemical Name or Material: G418 disulfate

• Color: Undesignated
• Quantity: 50mL
• MDL Number: MFCD00058314
• Solubility Information: Difficult to mix.
• SMILES: CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
• Molecular Weight (g/mol): 692.702
• Formula Weight: 692.71

Safety and Handling

Product Identifier

• G418 disulfate, 50mg/ml solution

Signal Word

• Danger

Hazard Category

• Respiratory sensitiser Category 1
• Skin sensitiser Category 1

Hazard Statement

• H317-May cause an allergic skin reaction.
• H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P284-¢In case of inadequate ventilation! wear respiratory protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
• P342+P311-If experiencing respiratory symptoms: Call a POISON CENTER/doctor/ .

Supplemental information

• MIXTURE LIST-Contains : D-Streptamine, O-2-amino-2,7-dideoxy-D-glycero-.alpha.-D -gluco-heptopyranosyl-(1->4)-O-[3-deoxy-4-