Invitrogen™ FZD7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA592165

Product Code. 16508161

Description

Immunogen sequence: MRDPGAAAPL SSLGLCALVL ALLGALSAGA GAQPYHGEKG ISVPDHGFCQ PISIPLCTDI AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF FLCSMYAPVC TVLDQAIPPC RSLCERARQG CEALMNKFGF QWPERLRCEN FPVHGAGEIC VGQNTSDGSG GPGGGPTAYP TAPYLPDLPF TALPPGASDG RGRPAFPFSC PRQLKVPPYL GYRFLGERDC GAPCEPGRAN GLMYFKEEER RFARLWVGVW; Positive Samples: SW480, Mouse kidney; Cellular Location: Cell membrane, Membrane, Multi-pass membrane protein.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

Specifications

• Antigen: FZD7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FZD7
• Gene Alias: frizzled 7, seven transmembrane spanning receptor; frizzled class receptor 7; frizzled family receptor 7; frizzled homolog 7; frizzled homolog 7 (Drosophila); Frizzled, drosophila, homolog of, 7; frizzled-7; Fz7; Fz-7; FZD7; FzE3; hFz7; LOC100360552; mFz7; rCG22430-like; rizzled 7
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14369, 8324
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.52 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O75084, Q61090
• Gene Symbols: FZD7
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human FZD7 (NP_0034981).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG