Invitrogen™ FUT8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5113479

Product Code. 17191334

Description

FUT8 Polyclonal Antibody for Western Blot, IHC (P), ELISA

Alpha-(1,6)-fucosyltransferase (FUT8) is a gene located on chromosome 14q23.3, encoding an enzyme that catalyzes the addition of fucose to N-glycans via alpha-1,6-linkage. This fucosylation is important in modifying glycoproteins, influencing their function, stability, and interactions within biological systems. FUT8 activity is crucial in various physiological processes, including immune regulation, cell signaling, and development. Aberrant fucosylation patterns, due to altered FUT8 expression, have been associated with pathological conditions such as cancer and inflammatory diseases. In oncology, FUT8-mediated core fucosylation of glycoproteins is linked to tumor progression, metastasis, and therapeutic resistance, making it a potential biomarker for cancer diagnosis and prognosis. Additionally, FUT8's role in immune function highlights its involvement in cellular communication and homeostasis, offering insights into therapeutic strategies aimed at modulating glycosylation pathways to address disease states.

Specifications

• Antigen: FUT8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FUT8
• Gene Alias: alpha (1,6) fucosyltransferase; alpha-(1,6)-fucosyltransferase; alpha-1,6-fucosyltransferase; alpha1-6FucT; EC 2.4.1.68; Fucosyltransferase 8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); FUT8; GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 2530, 53618
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: Q9BYC5, Q9WTS2
• Gene Symbols: FUT8
• Immunogen: Recombinant Human Alpha-(1,6)-fucosyltransferase protein (247-377AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG