Invitrogen™ Fumarase Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA582967

Product Code. 16369924

Description

Immunogen sequence: HFPLVVWQTG SGTQTNMNVN EVISNRAIEM LGGELGSKIP VHPNDHVNKS QSSNDTFPTA MHIAAAIEVH EVLLPGLQKL HDALDAKSKE FAQIIK Highest antigen sequence indentity to the following orthologs: Mouse - 95%, Rat - 95%.

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

Specifications

• Antigen: Fumarase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FH
• Gene Alias: EF-3; Fh; Fh1; Fh-1; FMRD; fumarase; fumarate hydratase; fumarate hydratase 1; fumarate hydratase, mitochondrial; HLRCC; LRCC; MCL; MCUL1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2271
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P07954
• Gene Symbols: FH
• Immunogen: Recombinant protein corresponding to Human FH. Recombinant protein control fragment (Product #RP-94049).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG