Fucosyltransferase 3/FUT3 Antibody (SPM194) - IHC-Prediluted, Novus Biologicals™

Mouse Monoclonal Antibody

Brand:  Novus Biologicals NBP2-48372

Product Code. 18123369

Description

Fucosyltransferase 3/FUT3 Monoclonal specifically detects Fucosyltransferase 3/FUT3 in Human, Guinea Pig samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Blood Group Lewis b
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Symbols: FUT3
• Immunogen: Mucin isolated from a human ovarian cyst fluid (Uniprot: P21217)
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Gene ID (Entrez): 2525
• Target Species: Human, Guinea Pig
• Form: Purified

• Applications: Immunohistochemistry (Paraffin)
• Clone: SPM194
• Dilution: Immunohistochemistry-Paraffin
• Gene Alias: alpha-(1,3/1,4)-fucosyltransferase, Blood group Lewis alpha-4-fucosyltransferase, CD174, EC 2.4.1, EC 2.4.1.65, FT3B, Fucosyltransferase 3, fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group), Fucosyltransferase III, FucT-III, galactoside 3(4)-L-fucosyltransferase, LEfucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood groupincluded), Les, Lewis FT, MGC131739
• Host Species: Mouse
• Molecular Weight of Antigen: 45 kDa
• Quantity: 7 mL
• Primary or Secondary: Primary
• Test Specificity: The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.
• Content And Storage: Store at 4C.
• Isotype: IgG1 κ