Invitrogen™ FSTL3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA579285

Product Code. 15964855

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human U2OS whole cell, human Hela whole cell, human A549 whole cell, human PC-3 whole cell, human HepG2 whole cell, human K562 whole cell, rat liver tissue, rat testis tissue, rat NRK whole cell, mouse liver tissue, mouse testis tissue, mouse lung tissue.

Follistatin-like 3 (FSTL3) is a gene located on chromosome 19p13.3 and encodes a secreted glycoprotein that belongs to the follistatin-related protein family. FSTL3 functions as an antagonist to members of the transforming growth factor-beta (TGF-β) superfamily, particularly inhibiting activin and myostatin signaling. This inhibitory action is crucial for regulating muscle growth, fertility, and inflammation. FSTL3 is expressed in various tissues, including the placenta, gonads, and skeletal muscle, where it modulates physiological processes by binding to and neutralizing the activities of its target ligands. Dysregulation of FSTL3 has been implicated in conditions such as muscle wasting, metabolic syndrome, and reproductive disorders, reflecting its role in maintaining tissue homeostasis and function. Research into FSTL3 focuses on its potential therapeutic applications in diseases involving TGF-β pathway dysregulation, offering insights into strategies for modulating growth factor activities in clinical settings.

Specifications

• Antigen: FSTL3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FSTL3
• Gene Alias: E030038F23Rik; FLRG; FLRGFSRP; follistatin like 3; follistatin-like 3; follistatin-like 3 (secreted glycoprotein); follistatin-like protein 3; Follistatin-related gene protein; follistatin-related protein 3; FSRP; FSTL3; UNQ674/PRO1308
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10272, 114031, 83554
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
• Gene Accession No.: O95633, Q99PW7, Q9EQC7
• Gene Symbols: FSTL3
• Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human FSTL3 (145-159aa ECELRAARCRGHPDL).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG