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FSHR Polyclonal Antibody, Invitrogen™

Product Code. 13412887
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Quantity:
100 μL
Unit Size:
100µL
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13412887 100 μL 100µL
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Product Code. 13412887 Supplier Invitrogen Supplier No. PA528764

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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A431, H1299, HeLa, HepG2, Raji. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
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Specifications

Antigen FSHR
Applications Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene FSHR
Gene Accession No. P23945
Gene Alias follicle stimulating hormone receptor; follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; Fshr; FSH-R; FSHR1; FSHRO; LGR1; ODG1
Gene Symbols FSHR
Host Species Rabbit
Immunogen Synthetic peptide corresponding to a region within amino acids 631 and 695 of Human FSH Receptor
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2492
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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