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Invitrogen™ FRMPD4 Polyclonal Antibody

Product Code. 12848962
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Quantity:
100 μg
Unit Size:
100µg
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12848962 100 μg 100µg
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Product Code. 12848962 Supplier Invitrogen™ Supplier No. PA520841

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Description

Rabbit Polyclonal Antibody

A suggested positive control is SK-N-SH cell lysate. PA5-20841 can be used with blocking peptide PEP-0955.

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus. It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions. Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width; conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology. The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FRMPD4
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene FRMPD4
Gene Accession No. Q14CM0
Gene Alias FERM and PDZ domain containing 4; FERM and PDZ domain-containing protein 4; FRMPD4; KIAA0195; KIAA0316; PDZ domain-containing protein 10; PDZD10; PDZK10; Preso; PSD-95-interacting FERM and PDZ domain protein; PSD-95-interacting regulator of spine morphogenesis; TMEM94; Transmembrane protein 94
Gene Symbols FRMPD4
Host Species Rabbit
Immunogen An 18 amino acid peptide from near the center of human FRMPD4.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9758
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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