Invitrogen™ FREM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5120413

Product Code. 17731814

Description

Positive test controls include: Jurkat, HepG2, 293T. The target is usually found in the following locations: Cell membrane, Extracellular side, Single-pass type I membrane protein. Immunogen sequence: QPAAFGRALL SPGLAGAAGV PAEEAIVLAN RGLRVPFGRE VWLDPLHDLV LQVQPGDRCA VSVLDNDALA QRPGRLSPKR FPCDFGPGEV RYSHLGARSP SRDRVRLQLR YDAPGGAVVL PLVLEVEVVF TQLEVVTRNL PLVVEELLGT SNALDARSLE FAFQPETEEC RVGILSGLGA LPRYGELLHY PQVPGGAREG GAPETLLMDC KAFQELGVRY RHTAASRSPN RDWIPMVVEL RSRGAPVGSP ALKR.

FREM2 is a member of the FRAS1-related extracellular matrix protein family and like FREM1, mutations in the FREM2 gene are associated with Fraser syndrome. FREM2 localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes and is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The FREM2 gene is one of several genes whose transcription is affecteded by TFAP2C, a transcription factor involved in mammary development, differentiation, and oncogenesis.

Specifications

• Antigen: FREM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FREM2
• Gene Alias: 6030440P17Rik; 8430406N05Rik; b2b1562Clo; ECM3 homolog; FRAS1 related extracellular matrix protein 2; FRAS1-related extracellular matrix protein 2; FREM2; Gm409; my; ne; NV domain containing protein NV1; NV domain-containing protein 1; Nv1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 242022, 341640
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.43 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q5SZK8, Q6NVD0
• Gene Symbols: FREM2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 47-300 of human FREM2 (NP_997244.4).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG