missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ FRAX 597

Tocris Bioscience™ FRAX 597
GREENER_CHOICE

Product Code. 18788198
Change view
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
18788198 50 mg 50mg
18761358 10 mg 10mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 18788198 Supplier Tocris Bioscience™ Supplier No. 6029/50

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Potent group I PAK inhibitor

FRAX 597 is a potent group I PAK inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). FRAX 597 exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 >10 μM for PAK4). FRAX 597 inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material FRAX 597
CAS 1286739-19-2
Synonym 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one
Quantity 50 mg
Solubility Soluble to 20mM in DMSO
Target PAK Inhibitors
Molecular Formula C29H28ClN7OS
Formula Weight 558.1
Physical Form Solid
Color Yellow
Product Type Bioactive Small Molecule
Purity >98%
Show More Show Less

For Research Use Only.

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.