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  5. Tocris Bioscience™ FRAX 597

Tocris Bioscience™ FRAX 597
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Product Code. 18761358
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Product Code. 18761358 Supplier Tocris Bioscience™ Supplier No. 6029/10

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Description

Potent group I PAK inhibitor

FRAX 597 is a potent group I PAK inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). FRAX 597 exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 >10 μM for PAK4). FRAX 597 inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.
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Specifications

Chemical Name or Material FRAX 597
CAS 1286739-19-2
Synonym 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one
Quantity 10 mg
Solubility Soluble to 20mM in DMSO
Target PAK Inhibitors
Molecular Formula C29H28ClN7OS
Formula Weight 558.1
Physical Form Solid
Color Yellow
Product Type Bioactive Small Molecule
Purity >98%
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