FOXRED2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA534345

Product Code. 15315271

Description

A suggested positive control is human lung tissue lysate. PA5-34345 can be used with blocking peptide PEP-1388.

FOXRED2, also known as ERFAD, is an endoplasmic reticulum (ER) luminal flavoprotein which may function in ER associated degradation (ERAD). It has been proposed to bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. Upon knockdown of FOXRED2, the degradation of the ERAD model substrate ribophorin 332 is delayed, and the overall level of polyubiquitinated cellular proteins is decreased. Defects in the related protein FOXRED1 are a cause of mitochondrial complex I deficiency (MT-C1D), suggesting the FOXRED2 may also play a role in MT-C1D.

Specifications

• Antigen: FOXRED2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FOXRED2
• Gene Alias: Endoplasmic reticulum flavoprotein associated with degradation; ER flavoprotein associated with degradation; ERFAD; FAD dependent oxidoreductase domain containing 2; FAD-dependent oxidoreductase domain containing 2; FAD-dependent oxidoreductase domain-containing protein 2; FOXRED2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80020
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8IWF2
• Gene Symbols: FOXRED2
• Immunogen: A 17 amino acid synthetic peptide near the amino terminus of human FOXRED2
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG