FoxP3 Mouse, Clone: SPM579, Novus Biologicals™

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
18167933	Novus Biologicals NBP2-34385-0.02MG	0.02 mg
18127522	Novus Biologicals NBP2-34385-0.1MG	0.1 mg

Description

FoxP3 Monoclonal specifically detects FoxP3 in Human, Mouse, Monkey samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: FoxP3
• Dilution: Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug, Immunohistochemistry-Paraffin 0.5-ug/ml
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human, Mouse, Primate
• Gene Accession No.: Q9BZS1
• Gene ID (Entrez): 50943
• Immunogen: Full-length human FOXP3 protein
• Primary or Secondary: Primary
• Content And Storage: Store at 4C.
• Molecular Weight of Antigen: 51 kDa

• Clone: SPM579
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: Adaptive Immunity, Cell Biology, Chromatin Research, Immunology, Transcription Factors and Regulators
• Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
• Gene Alias: AIID, AIIDMGC141961, DIETER, forkhead box P3, Forkhead Box Protein P3, FOXP3delta7, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked, IPEX, JM2, MGC141961, MGC141963, PIDX, PIDXMGC141963, Scurfin, XPID, XPIDpolyendocrinopathy, enteropathy, X-linked
• Gene Symbols: FOXP3
• Isotype: IgG1 κ
• Purification Method: Protein A purified
• Test Specificity: Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.