Invitrogen™ FOXP3 Monoclonal Antibody (FJK-16s), Brilliant Violet™ 421, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Product Code	Brand	Quantity
17877120	Invitrogen™ 404-5773-80	25 μg
17887120	Invitrogen™ 404-5773-82	100 μg

Description

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.

Specifications

• Antigen: FOXP3
• Concentration: 0.2 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with BSA and 0.09% sodium azide; pH 7.2
• Gene Alias: AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
• Gene Symbols: Foxp3
• Primary or Secondary: Primary
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Gene: Foxp3

• Clone: FJK-16s
• Applications: Flow Cytometry
• Conjugate: Brilliant Violet 421
• Host Species: Rat
• Target Species: Bovine, Canine, Feline, Mouse, Pig, Rat
• Gene Accession No.: Q99JB6
• Gene ID (Entrez): 100037405, 20371, 317382, 444998, 491876, 506053
• Isotype: IgG2a κ
• Purification Method: Affinity chromatography
• Product Type: Antibody