Invitrogen™ FOXP2 Chimeric Recombinant Rabbit Monoclonal Antibody (RAB-S249)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA548344

Product Code. 17950841

Description

Specificity: This antibody recognizes FOXP2 (Forkhead box protein P2). It binds to a folded domain, amino acids 306-411. FOXP2 is a transcriptional repressor that plays a role in the specification and differentiation of lung epithelium.

FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.

Specifications

• Antigen: FOXP2 Chimeric
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% ProClin 300
• Gene Accession No.: O15409
• Gene Symbols: FOXP2
• Immunogen: This antibody was obtained by recombinant antibody (rAb) phage display recognizing FOXP2 protein under non-denaturing conditions.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG κ

• Applications: ELISA, Flow Cytometry, Immunoprecipitation, Immunocytochemistry
• Clone: RAB-S249
• Conjugate: Unconjugated
• Gene: FOXP2
• Gene Alias: 2810043D05Rik; AI449000; CAG repeat protein 44; CAG-16; CAGH44; D0Kist7; DKFZp686H1726; forkhead box P2; forkhead box protein P2; forkhead/winged-helix transcription factor; FOXP2; OTTHUMP00000196932; RGD1559697; SPCH1; TNRC10; trinucleotide repeat containing 10; trinucleotide repeat-containing gene 10 protein
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 93986
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid