Invitrogen™ FOXL2 Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA518175

Product Code. 11366143

Description

This antibody is predicted to react with bovine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

FOXL2 is a winged helix/forkhead transcription factor that is highly conserved in human, goat, mouse, and certain aquatic species. Given its cross-species conservation, it appears to play a critical role evolutionarily, likely in ovarian differentiation in mammals and in ovarian somatic cell differentiation and in further follicle development and/or maintenance. Immunohistochemical data shows that FOXL2 is a nuclear protein specifically expressed in eyelids and in fetal and adult ovarian follicular cells. It does not undergo any major posttranslational modifications. FOXL2 is also found to be associated with blepharo-phimosis/ptosis/epicanthus inverses syndrome (BPES). There are two forms of BPES. Type I BPES shows eyelid abnormal-ities that are associated with ovarian failure. In type II BPES, only eyelid defects are found. Studies have shown that FOXL2 is expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles.

Specifications

• Antigen: FOXL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FOXL2
• Gene Alias: AU045128; Blepharophimosis; BPES; BPES1; epicanthus inversus; forkhead box L2; forkhead box protein L2; forkhead transcription factor; forkhead transcription factor FOXL2; forkhead transcription factor L2; Foxl2; LUSTR2; MGC14393; Pfrk; P-Frk; PINTO; pituitary forkhead factor; POF3; putative transcription factor foxl2
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 26927, 668
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O88470, P58012
• Gene Symbols: FOXL2
• Immunogen: Synthetic peptide sequence (DSKTGALHSRLDL) corresponding to the C-terminus amino acids of FOXL2 (aa 364-376).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG