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FOXA2, eFluor 660, clone: 3C10, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-4778-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15569956

  • £172.54 / 100µg


Estimated Shipment date
from Supplier 27-06-2018
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Description

Description

Description: This 3C10 monoclonal antibody reacts with human FOXA2, which is also known as hepatocyte nuclear factor 3 beta (HNF3B). This 48-kDa member of the Forkhead family of transcription factors is expressed in the liver, pancreas (islets and some acinar cells), lung, and intestine. During development, FOXA2 is necessary for lung bud and pancreatic beta cell formation. Recently, directed expression of FOXA2 in embryonic stem cells has been found to regulate the generation and differentiation of midbrain dopaminergic neurons. It has also been shown to regulate genes involved hepatic lipid metabolism, including alpha fetoprotein, albumin, and transthyretin, as well as Pdx1 in the pancreas. FOXA2 expression is negatively regulated by insulin and reports demonstrate a role for it in sporadic cases of maturity-onset diabetes of the young and the epithelial-to-mesenchymal transition in cancer.Applications Reported: This 3C10 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.Applications Tested: This 3C10 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using low pH antigen retrieval and can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

FoxA2
Monoclonal
0.2mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q9Y261
HNF3B
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry
3C10
eFluor 660
FOXA2
Conjugated
FOXA2
IgG1
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary
3170
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