FoxA2 Mouse anti-Human, eFluor 660, Clone: 3C10, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-4778-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15569956

Quantity Price
1 £ 167.38 / 100µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Applications Immunohistochemistry (Formalin/Paraffin)
Isotype IgG1
Clone 3C10
Antigen FoxA2
Format Conjugated
Quantity 100μg
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 0.2mg/mL
Monoclonal or Polyclonal Monoclonal
Conjugate eFluor 660
Gene Alias Hepatocyte nuclear factor 3 beta
Host Species Mouse
Regulatory Status RUO
Primary or Secondary Primary
Species Reactivity Human
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

This 3C10 monoclonal antibody reacts with human FOXA2, which is also known as hepatocyte nuclear factor 3 beta (HNF3B). This 48kDa member of the Forkhead family of transcription factors is expressed in the liver, pancreas (islets and some acinar cells), lung, and intestine. During development, FOXA2 is necessary for lung bud and pancreatic beta cell formation. Recently, directed expression of FOXA2 in embryonic stem cells has been found to regulate the generation and differentiation of midbrain dopaminergic neurons. It has also been shown to regulate genes involved hepatic lipid metabolism, including alpha fetoprotein, albumin, and transthyretin, as well as Pdx1 in the pancreas. FOXA2 expression is negatively regulated by insulin and reports demonstrate a role for it in sporadic cases of maturity-onset diabetes of the young and the epithelial-to-mesenchymal transition in cancer.