Thermo Scientific Chemicals Fluconazole, 98%

Product Code	Brand	Quantity
15365008	Thermo Scientific Chemicals 455480010	1 g
15375008	Thermo Scientific Chemicals 455480050	5 g

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species

• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity

• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)

• Mammalian cell demethylation is much less susceptible to fluconazole inhibition

Applications

• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.

• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene

• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays

• It has also been used as a positive control in antifungal assay of plants

Chemical Identifiers

• CAS: 86386-73-4
• Molecular Weight (g/mol): 306.27
• Synonym: fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol
• ChEBI: CHEBI:46081
• SMILES: C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O

• Molecular Formula: C₁₃H₁₂F₂N₆O
• InChI Key: RFHAOTPXVQNOHP-UHFFFAOYSA-N
• PubChem CID: 3365
• IUPAC Name: 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol

Specifications

• CAS: 86386-73-4
• Loss on Drying: 1% max. (105°C, 3 h)
• Assay Percent Range: 97.5% min. (HPLC)
• Molecular Formula: C₁₃H₁₂F₂N₆O
• Solubility Information: Solubility in water: <1mg/mL at 25 deg c. Other solubilities: solubility in ethanol: 61mg/mL at 25 deg c, solubility in dmso: 61mg/mL at 25 deg c
• SMILES: C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O
• Molecular Weight (g/mol): 306.27
• ChEBI: CHEBI:46081
• Percent Purity: 98%

• Melting Point: 137.0°C to 141.0°C
• Infrared Spectrum: Authentic
• Packaging: Glass Bottle
• Synonym: fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol
• InChI Key: RFHAOTPXVQNOHP-UHFFFAOYSA-N
• IUPAC Name: 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
• PubChem CID: 3365
• Formula Weight: 306.27
• Chemical Name or Material: Fluconazole

Safety and Handling

GHS H Statement
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May damage the unborn child.

GHS P Statement
IF ON SKIN: Wash with plenty of soap and water.
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses,if present and easy to do.
Continue rinsing.
IF INHALED: Remove to fresh air and kee

GHS Signal Word: Warning

Product Identifier

• Fluconazole

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Reproductive toxicity Category 1B
• Skin corrosion/irritation Category 2

Hazard Statement

• H360D-May damage the unborn child.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H302-Harmful if swallowed.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.
• P362-Take off contaminated clothing.

RUO – Research Use Only