Thermo Scientific Chemicals Fluconazole, 98%

Product Code.	Quantity	unitSize
15365008	1 g	1g
15375008	5 g	5g

Product Code. 15365008 Supplier Thermo Scientific Chemicals Supplier No. 455480010

Description

Fluconazole, 98%, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase. | CAS: 86386-73-4 | C₁₃H₁₂F₂N₆O | 306.27 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species

• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity

• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)

• Mammalian cell demethylation is much less susceptible to fluconazole inhibition

Applications

• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.

• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene

• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays

• It has also been used as a positive control in antifungal assay of plants

Specifications

Chemical Identifiers

• CAS: 86386-73-4
• Molecular Formula: C₁₃H₁₂F₂N₆O
• Molecular Weight (g/mol): 306.27
• InChI Key: RFHAOTPXVQNOHP-UHFFFAOYSA-N
• Synonym: fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol
• PubChem CID: 3365
• ChEBI: CHEBI:46081
• IUPAC Name: 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
• SMILES: C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O

• Melting Point: 137.0°C to 141.0°C
• Loss on Drying: 1% max. (105°C, 3 h)
• Infrared Spectrum: Authentic
• Assay Percent Range: 97.5% min. (HPLC)
• Packaging: Glass Bottle
• Quantity: 1 g
• Solubility Information: Solubility in water: <1mg/mL at 25 deg c. Other solubilities: solubility in ethanol: 61mg/mL at 25 deg c, solubility in dmso: 61mg/mL at 25 deg c
• Formula Weight: 306.27
• Percent Purity: 98%
• Chemical Name or Material: Fluconazole

Seguridad y manipulación

Nombre del producto

• Fluconazole

Palabra de advertencia

• Danger

Clasificación

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Reproductive toxicity Category 1B
• Skin corrosion/irritation Category 2

Indicaciones de peligro

• H360D-May damage the unborn child.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H302-Harmful if swallowed.

Consejos de prudencia

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.
• P362-Take off contaminated clothing.

SDS

RUO – Research Use Only