FLT4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA5109731

Product Code. 17137663

Description

Immunogen sequence: QGRGLQEEEE VCMAPRSSQS SEEGSFSQVS TMALHIAQAD AEDSPPSLQR HSLAARYYNW VSFPGCLARG AETRGSSRMK TFEEFPMTPT TYKGSVDNQT DSGMVLASEE FEQIESRHRQ ESGFSCKGPG QNVAVTRAHP DSQGRRRRPE RGARGGQVFY NSEYGELSEP SEEDHCSPSA RVTFFTDNSY

Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.

Specifications

• Antigen: FLT4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FLT4
• Gene Alias: AI323512; Chy; chylous ascites; Flt4; FLT-4; FLT41; fms related tyrosine kinase 4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; PCL; receptor protein tyrosine kinase; soluble VEGFR 3; sVEGFR 3; tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGF R3; VEGFR3; VEGFR-3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114110, 14257, 2324
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.99 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P35916, P35917, Q91ZT1
• Gene Symbols: FLT4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1174-1363 of human VEGFR3/FLT4 (NP_8915552)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG