Invitrogen™ Human FLT3 [D835Y], His Tag Recombinant Protein

Product Code. 15458593

Brand: Invitrogen™ PR7450A

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Cytoplasmic

FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Specifications

• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50 mM tris HCl with 0.05% NP-40, 0.5 mM EDTA, 100 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5
• Molecular Weight (g/mol): 48.6 kDa
• Name: Human FLT3 [D835Y], His Tag
• Quantity: 100 μg
• Regulatory Status: RUO - research use only
• Common Name: FLT3 (D835Y Mutant)
• KinaseFamily: PDGFR Kinase Family
• Protein Length: 564-958; D835Y
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-tag
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Expression System: Insect cells
• Form: Liquid