Invitrogen™ FKBP12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA514852

Product Code. 10282600

Description

This antibody is predicted to react with bovine, mouse, rat and rabbit based on sequence homology.

FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.

Specifications

• Antigen: FKBP12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FKBP1A
• Gene Alias: 12 kDa FK506-binding protein; 12 kDa FKBP; calstabin 1; calstabin-1; EC 5.2.1.8; FK506 binding protein 1a; FK506 binding protein 1A, 12kDa; FK506 binding protein 2 (13 kDa); FK506 binding protein12; FK506-binding protein 1; FK506-binding protein 1 (12kD); FK506-binding protein 12; FK506-binding protein 1a; FK506-binding protein 1A (12kD); FK506-binding protein, T-cell, 12-kD; Fkbp; FKBP1; FKBP12; FKBP-12; FKBP12-Exip3; Fkbp1a; FKBP-1A; Fkbp2; Immunophilin FKBP12; peptidyl-prolyl cis-trans isomerase FKBP1A; PKC12; PKCI2; PPIASE; PPIase FKBP1A; protein kinase C inhibitor 2; rotamase
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 2280
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: P62942
• Gene Symbols: FKBP1A
• Immunogen: KLH conjugated synthetic peptide between 43-74 amino acids from the central region of human FKBP12.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG