Invitrogen™ Filamin A alpha-2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA529598

Product Code. 13463777

Description

Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse kidney, PC-12, Rat2. Predicted reactivity: Mouse (98%), Rat (98%), Rabbit (98%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: Filamin A alpha-2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FLNA
• Gene Alias: ABP-280; ABPX; actin binding protein 280; actin-binding protein 280; alpha filamin; alpha-filamin; CSBS; CVD1; dilated pupils 2; Dilp2; Endothelial actin-binding protein; Endothelial actin-binding protein 280); F730004A14Rik; filamin A; filamin A, alpha; filamin, alpha; filamin-1; Filamin-A; FLN; FLN1; FLNA; FLN-A; FMD; GENA 379; MNS; NHBP; Non-muscle filamin; OPD; OPD1; OPD2; RGD1560614; XLVD; XMVD
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 192176, 2316, 293860
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.42 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P21333, Q8BTM8
• Gene Symbols: FLNA
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human Filamin A. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG