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Filaggrin Antibody (FLG/1563) - Azide and BSA Free, Novus Biologicals™

Product Code. 18334390 Shop All Bio Techne Products
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100 μg
Unit Size:
100µg
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18334390 100 μg 100µg
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Product Code. 18334390 Supplier Novus Biologicals Supplier No. NBP275774

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Beskrivning

Mouse Monoclonal Antibody

Filaggrin Monoclonal specifically detects Filaggrin in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen Filaggrin
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone FLG/1563
Concentration 0.2 mg/ml
Conjugate Unconjugated
Dilution Immunohistochemistry-Paraffin 0.5-1 ug/ml
Formulation 10 mM PBS with No Preservative
Gene Accession No. P20930
Gene Alias ATOD2, epidermal filaggrin, filaggrin, Profilaggrin
Gene Symbols FLG
Host Species Mouse
Immunogen Recombinant human Filaggrin protein fragment (around aa 998-1104) (exact sequence is proprietary) (Uniprot: P20930)
Purification Method Protein A or G purified
Quantity 100 μg
Research Discipline Cytoskeleton Markers
Primary or Secondary Primary
Gene ID (Entrez) 2312.0
Test Specificity Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Target Species Human
Content And Storage Store at 4°C.
Form Purified
Isotype IgG2b κ
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