Invitrogen™ Filaggrin 2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA555951

Product Code. 15703871

Description

Immunogen sequence: CGYSNSSGCG RPQNASSSCQ SHRFGGQGNQ FSYIQSGCQS GIKGGQGHGC VSGGQPSGCG QPESNPCSQS YSQRGYGARE NGQPQNCGGQ WRTGSSQSSC CG Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 35%.

The FLG2 protein is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. FLG2 is also required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa.

Specifications

• Antigen: Filaggrin 2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FLG2
• Gene Alias: filaggrin family member 2; filaggrin-2; FLG2; FLG-2; Ifapsoriasin; IFPS; intermediate filament-associated and psoriasis susceptibility protein; intermediate filament-associated and psoriasis-susceptibility protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 388698
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5D862
• Gene Symbols: FLG2
• Immunogen: Recombinant protein corresponding to Human Filaggrin 2. Recombinant protein control fragment (Product #RP-94294).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG