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Tocris Bioscience™ FIIN 1 hydrochloride

Product Code. 18005452
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Quantity:
2 mg
Unit Size:
2mg
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Product Code. 18005452

Brand: Tocris Bioscience™ 4002/2

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Description

Potent, irreversible FGFR inhibitor

FIIN 1 hydrochloride is a potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044).
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide
CAS 1256152-35-8
Quantity 2 mg
Target FGF Receptor Inhibitors
Molecular Formula C32H39Cl2N7O4
Purity 96%
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