Invitrogen™ Fibrillarin/FBLL1 Recombinant Rabbit Monoclonal Antibody (HL2588)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA556708

Product Code. 30276389

Description

Fibrillarin/FBLL1 Recombinant Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

Fibrillarin, encoded by the FBL gene (also known as FBLL1), is a highly conserved nucleolar protein that plays a critical role in the biogenesis of ribosomes. It is a component of the small nucleolar ribonucleoprotein (snoRNP) complexes and is primarily involved in the chemical modification of ribosomal RNA (rRNA), specifically in the methylation of the 2'-O-ribose residues of rRNA. This modification is essential for the proper processing and maturation of pre-rRNA into functional ribosomal subunits, which are crucial for protein synthesis within the cell. Fibrillarin is not only important for ribosome production but also for maintaining the structural integrity of the nucleolus, the site of ribosome assembly. Dysregulation or mutations in the FBL gene have been associated with various human diseases, including cancer, where altered ribosome biogenesis can contribute to uncontrolled cell proliferation. Additionally, fibrillarin has been studied in the context of autoimmune diseases, such as systemic sclerosis, where it can serve as an autoantigen. Understanding the function and regulation of fibrillarin is vital for insights into cellular growth, protein synthesis, and the pathogenesis of related diseases.

Specifications

• Antigen: Fibrillarin/FBLL1
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: A6NHQ2, P22087, P22509, P35550, Q80WS3
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 14113, 2091, 237730, 292747, 345630, 363563
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: HL2588
• Conjugate: Unconjugated
• Gene: FBLL1
• Gene Symbols: fbl, FBLL1
• Immunogen: Recombinant fragment of human fibrillarin.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG