Invitrogen™ FGR Monoclonal Antibody (6G2)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA515490

Product Code. 11355463

Description

MA5-15490 targets FGR in indirect ELISA, IHC and WB applications and shows reactivity with Human and mouse samples. The MA5-15490 immunogen is purified recombinant fragment of human FGR expressed in E. Coli. MA5-15490 detects FGR which has a predicted molecular weight of approximately 56kDa.

FGR is a SRC-related kinase present in hematopoietic cells. FGR signals within multiple pathways including within the integrin pathway and downstream of chemokine and cytokine receptors. This protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. It localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein.

Specifications

• Antigen: FGR
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Ascites with 0.03% sodium azide
• Gene Accession No.: P09769, P14234
• Gene Symbols: FGR
• Immunogen: Purified recombinant fragment of human FGR expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 14191, 2268
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 6G2
• Conjugate: Unconjugated
• Gene: FGR
• Gene Alias: c-fgr; c-fgr protooncogene; c-src2; c-src-2 proto-oncogene; EC 2.7.10.2; feline Gardner-Rasheed sarcoma viral oncogene; feline Gardner-Rasheed sarcoma viral oncogene homolog; FGR; FGR protein; FGR proto-oncogene, Src family tyrosine kinase; FLJ43153; Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; MGC75096; OTTHUMP00000003603; OTTHUMP00000003604; p55c-fgr; p55-c-fgr protein; p55-Fgr; p58c-Fgr; p58-Fgr; proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; SRC2; Tyrosine-protein kinase Fgr; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1