Invitrogen™ Human FGFR3 [K650E], His Tag Recombinant Protein

Product Code. 10443112

Brand: Invitrogen™ PV4428

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Cytoplasmic.

FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Specifications

• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris with 150mM NaCl, 50% glycerol, 0.02% Triton X-100, 0.5mM EDTA and no preservative; pH 7.5
• Molecular Weight (g/mol): 49.8 kDa
• Name: Human FGFR3 [K650E], His Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 1 mg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Common Name: FGFR3 (K650E Mutant)
• KinaseFamily: FGF Receptor Kinase Family
• Protein Length: 398-806; K650E
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: 398-806; K650E
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Kinase Group: Tyrosine Kinases
• Shipping Condition: Dry Ice
• Expression System: Baculovirus
• Protein Family: Growth Factors & Receptors
• Protein Form: Cytoplasmic
• Form: Liquid
• Protein Subtype: FGFs (Fibroblast Growth Factors)
• Research Category: Drug Development