Invitrogen™ FGF2 Monoclonal Antibody (FB-8)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA124682

Product Code. 11504762

Description

Recommended positive controls: recombinant human FGF2. This antibody does not cross react with human acidic FGF. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.

Specifications

• Antigen: FGF2
• Classification: Monoclonal
• Concentration: 2.3 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: P03969, P09038
• Gene Symbols: FGF2
• Immunogen: Recombinant human FGF2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Dot Blot, ELISA, Neutralization, Radioimmune Assays (RIA), Western Blot, Immunocytochemistry
• Clone: FB-8
• Conjugate: Unconjugated
• Gene: FGF2
• Gene Alias: Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); Fibroblast growth factor basic; HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 2247, 281161
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid