Invitrogen™ FBXW7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5120961

Product Code. 17792354

Description

Positive test controls include: Jurkat, SH-SY5Y, MCF7, mouse testis, rat heart. The target is usually found in the following locations: Cytoplasm, Nucleus, nucleolus, nucleoplasm. Immunogen sequence: PTGLQEWLKM FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR IDTNWRRGEL K.

F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW7 was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: FBXW7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FBXW7
• Gene Alias: 1110001A17Rik; AGO; archipelago; Archipelago homolog; CDC4; DKFZp686F23254; F-box and WD repeat domain containing 7; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; f-box only protein 30; F-box protein FBW7; F-box protein FBX30; F-box protein Fbxw6; F-box protein SEL-10; F-box/WD repeat-containing protein 7; F-box-WD40 repeat protein 6; FBW6; FBW7; Fbwd6; FBX30; Fbxo30; FBXW6; FBXW7; FLJ11071; FLJ16457; hAgo; hCdc4; homolog of C elegans sel-10; SEL10; SEL-10
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100360914, 50754, 55294
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.71 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: Q8VBV4, Q969H0
• Gene Symbols: FBXW7
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 231-371 of human FBXW7.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG