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Invitrogen™ FBXW7 Polyclonal Antibody
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Product Code. 17792354
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Quantity:
100 μL
Unit Size:
100µL
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17792354 100 μL 100µL
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Product Code. 17792354 Supplier Invitrogen™ Supplier No. PA5120961

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Description

Rabbit Polyclonal Antibody

Positive test controls include: Jurkat, SH-SY5Y, MCF7, mouse testis, rat heart. The target is usually found in the following locations: Cytoplasm, Nucleus, nucleolus, nucleoplasm. Immunogen sequence: PTGLQEWLKM FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR IDTNWRRGEL K.

F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW7 was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FBXW7
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.89 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene FBXW7
Gene Accession No. Q8VBV4, Q969H0
Gene Alias 1110001A17Rik; AGO; archipelago; Archipelago homolog; CDC4; DKFZp686F23254; F-box and WD repeat domain containing 7; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; f-box only protein 30; F-box protein FBW7; F-box protein FBX30; F-box protein Fbxw6; F-box protein SEL-10; F-box/WD repeat-containing protein 7; F-box-WD40 repeat protein 6; FBW6; FBW7; Fbwd6; FBX30; Fbxo30; FBXW6; FBXW7; FLJ11071; FLJ16457; hAgo; hCdc4; homolog of C elegans sel-10; SEL10; SEL-10
Gene Symbols FBXW7
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100360914, 50754, 55294
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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