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Invitrogen™ FBXL20 Polyclonal Antibody

Product Code. 12858662
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Quantity:
100 μg
Unit Size:
100µg
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12858662 100 μg 100µg
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Product Code. 12858662 Supplier Invitrogen™ Supplier No. PA520486

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Description

Rabbit Polyclonal Antibody

A suggested positive control is A-20 cell lysate. PA5-20486 can be used with blocking peptide PEP-0606.

Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FBXL20
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene FBXL20
Gene Accession No. Q96IG2, Q9CZV8, Q9QZH7
Gene Alias 2610511F20Rik; 4632423N09Rik; AI849362; AL117906; C86145; Fbl2; Fbl20; F-box and leucine rich repeat protein 20; F-box and leucine-rich repeat protein 20; F-box protein FBL2; F-box/LRR-repeat protein 20; F-box/LRR-repeat protein 2-like; Fbxl2; Fbxl20; mKIAA4147; Scr; scrapper
Gene Symbols FBXL20
Host Species Rabbit
Immunogen An 18 amino acid peptide near the amino terminus of the human SCRAPPER.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64039, 72194, 84961
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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