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Fas/TNFRSF6/CD95 Antibody (R-125224), mFluor Violet 450 SE, Novus Biologicals™

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Produktkod. 18413788 Leverantör Novus Biologicals Leverantörsnummer NBP281112MFV450

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Beskrivning

Human Monoclonal Antibody

Fas/TNFRSF6/CD95 Monoclonal antibody specifically detects Fas/TNFRSF6/CD95 in Human samples. It is validated for Flow Cytometry
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen Fas/TNFRSF6/CD95
Applications Flow Cytometry
Classification Monoclonal
Clone R-125224
Conjugate mFluor Violet 450 SE
Dilution Flow Cytometry
Formulation 50mM Sodium Borate
Gene Alias Apo-1 antigen, apoptosis antigen 1, Apoptosis-mediating surface antigen FAS, APT1FASTM, CD95 antigen, CD95ALPS1A, Fas (TNF receptor superfamily, member 6), Fas AMA, Fas antigen, FAS1, FASLG receptor, TNFRSF6member 6, tumor necrosis factor receptor superfamily member 6
Host Species Human
Immunogen R-125224 is generated by the humanization of the murine HFE7A anti-Fas/TNFRSF6/CD95 antibody by grafting the CDR regions to the framework regions of the human 8E10 antibody and substituting key framework residues from the murine antibody into the 8E10 sequence. The original HFE7A was derived from a hybridoma cell line generated by the fusion of NS1 myeloma cells with splenocytes from Fas-deficient mice which had been immunized with partially purified recombinant human Fas-AIC2A chimera protein consisting of the extracellular region of human Fas/TNFRSF6/CD95 antigen (aa -16 to 150) and the extracellular region of the murine IL-3 receptor AIC2 (aa 3-423). The HFE7A hybridoma was selected after screening by flow cytometry for the production of antibodies with the ability to bind to the WR19L12a transformed murine T cell lymphoma cell line expressing human Fas/TNFRSF6/CD95 or the L5178YA1 cell line expressing murine Fas/TNFRSF6/CD95, but not to the parental WR19L or L5178Y cells.
Purification Method Protein A purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Apoptosis, Cancer, Cell Biology, Death Receptor Signaling Pathway, Diabetes Research, Hematopoietic Stem Cell Markers, Immunology, Inhibitors Activators and Regulators, Innate Immunity, Signal Transduction, Stem Cells
Primary or Secondary Primary
Gene ID (Entrez) 355
Target Species Human
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG1 κ
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