Invitrogen™ FAM35A/FAM35B Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5104378

Product Code. 16690825

Description

Antibody detects endogenous levels of total FAM35A/B.

Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). [UniProt].

Specifications

• Antigen: FAM35A/FAM35B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FAM35A
• Gene Alias: 3110001K24Rik; bA163M19.1; Fam35a; FAM35A1; family with sequence similarity 35 member A; family with sequence similarity 35, member A; protein FAM35A; RINN1-REV7-interacting novel NHEJ regulator 2; RINN2; Shield complex subunit 2; Shieldin complex subunit 2; SHLD2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54537
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q86V20
• Gene Symbols: FAM35A
• Immunogen: A synthesized peptide derived from human FAM35A(Accession Q86V20), corresponding to amino acid residues S393-N443.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG