Invitrogen™ FALZ Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA583905

Product Code. 16390855

Description

Immunogen sequence: TTIASTGQTF QITGNPVTMA GKVITKLPLP ANSKIVAVNV PATQGGIVQV HQ Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 90%.

BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyses ATP-dependent nucleosome sliding and facilitates transcription. BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes. BPTF also exhibits some binding to H3 di-methylated at K4. BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors. While BPTF is expressed in low levels in the adult brain and spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases. It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer's disease. Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level).Tissue specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).

Specifications

• Antigen: FALZ
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BPTF
• Gene Alias: 9430093H17Rik; BPTF; bromodomain and PHD domain transcription factor; bromodomain and PHD finger-containing transcription factor; bromodomain PHD finger transcription factor; FAC1; FALZ; fetal Alz-50 clone 1 protein; fetal Alz-50 reactive clone 1; fetal Alzheimer antigen; nucleosome remodeling factor, large subunit; nucleosome-remodeling factor subunit BPTF; NURF301
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2186
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q12830
• Gene Symbols: BPTF
• Immunogen: Recombinant protein corresponding to Human BPTF. Recombinant protein control fragment (Product #RP-106184).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG