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Invitrogen™ FAIM3 Polyclonal Antibody

Product Code. 12848422
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12848422 100 μg 100µg
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Product Code. 12848422 Supplier Invitrogen™ Supplier No. PA520285

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Description

Rabbit Polyclonal Antibody

Despite its predicted molecular weight, Toso often migrates at 60kDa in SDS-PAGE. A suggested positive control is human lung tissue lysate. PA5-20285 can be used with blocking peptide PEP-0403.

Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FAIM3
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Fcmr
Gene Accession No. O60667
Gene Alias 1810037B05Rik; Faim3; Fas apoptotic inhibitory molecule 3; Fc fragment of IgM receptor; Fc mu receptor; FCMR; FcmuR; IgM Fc fragment receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso; TOSO
Gene Symbols Fcmr
Host Species Rabbit
Immunogen A 13 amino acid peptide from near the carboxy terminus of human Toso.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9214
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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