Invitrogen™ Human Factor XI Native Protein

Product Code. 11564111

Brand: Invitrogen™ RP43075

Description

Native Protein

RP-43075 contains native human Factor XI protein. RP-43075 may be used as a positive control in many immunological assays. The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests. This product is to be used for IN VITRO research purposes only, and is not intended for clinical or diagnostic use!

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.

Specifications

• Accession Number: P03951
• Concentration: 7.0 mg/mL
• For Use With (Application): Control
• Formulation: 50% water with 50% glycerol and no preservative
• Gene ID (Entrez): 2160
• Molecular Weight (g/mol): 160 kDa
• Name: Human Factor XI
• Quantity: 50 μg
• Source: Human
• Regulatory Status: RUO
• Gene Alias: 1600027G01Rik; AI503996; Cf11; Coagulation factor XI; Coagulation factor XIa heavy chain; Coagulation factor XIa light chain; F11; FXI; LRRGT00086; plasma thromboplastin antecedent; PTA
• Common Name: Factor XI
• Gene Symbol: F11
• Biological Activity: Specific Activity =372 U/mg; determined by Factor XI clotting assay where 1 U equals the Factor XI activity in 1 mL of normal human plasma.
• Conjugate: Unconjugated
• Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Protein Subtype: Native