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  6. Invitrogen™ Factor VIII Monoclonal Antibody (F8C-27.4), Invitrogen™

Invitrogen™ Factor VIII Monoclonal Antibody (F8C-27.4), Invitrogen™

Product Code. 17800276
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Product Code. 17800276 Supplier Invitrogen™ Supplier No. MA546008

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Description

Mouse Monoclonal Antibody

MA1-10590 recognizes an epitope in the N-terminal region of the 83kDa light chain of human Factor VIII. This antibody does not cross-react with von Willebrand factor. MA1-10590 has been successfully used in ELISA and Western blot applications. The MA1-10590 immunogen is purified human Factor VIII.

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Factor VIII
Applications ELISA, Western Blot
Classification Monoclonal
Clone F8C-27.4
Concentration 0.8 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene F8
Gene Accession No. P00451
Gene Alias AHF; Antihemophilic factor; CF8; Cf-8; coagulation factor VIII; coagulation factor VIII A1 domain; coagulation factor VIII C2 domain; coagulation factor VIII, procoagulant component; coagulation factor VIII, procoagulant component (hemophilia A); coagulation factor VIIIc; DXS1253E; F8; F8B; F8C; Factor 8; Factor VIII; Factor VIII B chain; factor VIII F8B; factor VIII precursor; Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIIIa light chain; factor8; FVIII; HEMA; Procoagulant component; RP11-115M6.7
Gene Symbols F8
Host Species Mouse
Immunogen Purified human Factor VIII.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2157
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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