F4/80 Antigen Rat anti-Mouse, Clone: BM8, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-4801-86

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15278627

Quantity Price
1 £ 298.99 / 1mg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Isotype IgG2a
Quantity 1mg
Conjugate Unlabeled
Applications Flow Cytometry
Formulation aqueous buffer, no sodium azide
Format Purified
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Gene Alias Pan Macrophage Marker
Host Species Rat
Primary or Secondary Primary
Clone BM8
Antigen F4/80 Antigen
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Concentration 1mg/mL

The BM8 monoclonal antibody reacts with mouse F4/80 antigen, an approximately 125kDa transmembrane protein. The F4/80 antigen is expressed by a majority of mature macrophages and is the best marker for this population of cells. However, other cell types such as Langerhans cells and liver Kupffer cells have been reported to express this antigen. Expression of F4/80 commences during early myeloid development and is upregulated on all BM cells stimulated in vitro with M-CSF. It has been shown that some cytokines downregulate the expression of F4/80 resulting in lack of F4/80 antigen on a subpopulation of macrophages, especially in the lymphoid microenvironment in vivo.