Invitrogen™ EYA2 Recombinant Rabbit Monoclonal Antibody (23GB5350), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA552843

Product Code. 30088467

Description

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.

Specifications

• Antigen: EYA2
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O00167, O08575
• Gene Symbols: EYA2
• Immunogen: A synthesized peptide derived from human EYA2 (20-50AA).
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry
• Clone: 23GB5350
• Conjugate: Unconjugated
• Gene: EYA2
• Gene Alias: Drosophila-type eyes absent 2-like protein; Eab1; EYA transcriptional coactivator and phosphatase 2; Eya2; eyes absent 2; eyes absent 2 homolog; eyes absent 2 homolog (Drosophila); eyes absent 2 isoform a; eyes absent homolog 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14049, 2139
• Content And Storage: -20°C
• Form: Liquid